{ "2'-F-CTP": { "zh": "2'-F-CTP" }, "2'-F-UTP": { "zh": "2'-F-UTP" }, "2'-OMe-ATP": { "zh": "2'-OMe-ATP" }, "2'-OMe-UTP": { "zh": "2'-OMe-UTP" }, "2'-acetal levulinic ester (ALE) phosphoramidite": { "zh": "2'-缩醛乙酰丙酸酯(ALE)亚磷酰胺" }, "32P-end-labeling": { "zh": "32P末端标记" }, "500 Å pore": { "zh": "500 Å孔径" }, "AGT": { "zh": "AGT" }, "AJIPHASE®": { "zh": "AJIPHASE®" }, "ANGPTL3": { "zh": "ANGPTL3" }, "AOF formulation": { "zh": "无动物及人源成分(AOF)配方" }, "API sameness": { "zh": "API同一性" }, "APOC3": { "zh": "APOC3" }, "ASCVD": { "zh": "动脉粥样硬化性心血管疾病" }, "ASGPR": { "zh": "去唾液酸糖蛋白受体" }, "ASMF": { "zh": "ASMF备案" }, "Adaptive Laboratory Evolution": { "zh": "适应性实验室进化" }, "Ajinomoto Bio-Pharma Services": { "zh": "味之素生物制药服务" }, "Ajinomoto OmniChem": { "zh": "Ajinomoto OmniChem" }, "Amide linker": { "zh": "酰胺接头" }, "Angiotensinogen": { "zh": "血管紧张素原" }, "Antibody-Drug Conjugate": { "zh": "抗体偶联药物" }, "BD value": { "zh": "BD交易价值" }, "BIOSECURE Act": { "zh": "《生物安全法案》" }, "BTT activation": { "zh": "BTT活化" }, "Bachem": { "zh": "Bachem" }, "BeBetter Med": { "zh": "必贝特" }, "Beyotime": { "zh": "碧云天" }, "Biologics License Application": { "zh": "生物制品上市许可申请" }, "Biomaide": { "zh": "博迈德" }, "BirA/AviTag": { "zh": "BirA/AviTag" }, "Bis-RNAi": { "zh": "Bis-RNAi" }, "C5": { "zh": "C5" }, "CDE": { "zh": "药品审评中心" }, "CDMO": { "zh": "合同开发与生产组织" }, "CID fragmentation": { "zh": "碰撞诱导解离(CID)碎裂" }, "CLEA-LentiKats lipase formulation": { "zh": "CLEA-LentiKats脂肪酶制剂" }, "CMC development timeline": { "zh": "CMC开发周期" }, "CPG support": { "zh": "CPG载体" }, "CTA": { "zh": "临床试验申请" }, "Calantha™": { "zh": "Calantha™" }, "Calf Intestinal Alkaline Phosphatase": { "zh": "小牛肠碱性磷酸酶" }, "Candida antarctica lipase B": { "zh": "南极假丝酵母脂肪酶B" }, "Category I": { "zh": "第I类" }, "Category II": { "zh": "第II类" }, "Category III": { "zh": "第III类" }, "Category IV": { "zh": "第IV类" }, "ChemGenes": { "zh": "ChemGenes" }, "Chinese IND": { "zh": "中国IND" }, "Class 3": { "zh": "第3类" }, "Complement Factor B": { "zh": "补体因子B" }, "Complete Response Letter": { "zh": "完全答复函" }, "Controlled pore glass": { "zh": "受控孔径玻璃" }, "Cross-Linked Enzyme Aggregates": { "zh": "交联酶聚集体" }, "CuAAC": { "zh": "铜催化叠氮-炔烃环加成" }, "D-galactosamine": { "zh": "D-半乳糖胺" }, "DBCO": { "zh": "二苯并环辛炔(DBCO)" }, "DMF": { "zh": "DMF备案" }, "DMT-on HPLC purification handle": { "zh": "DMT-on HPLC纯化把手" }, "DNase I": { "zh": "DNase I" }, "Deep Eutectic Solvent": { "zh": "深共熔溶剂" }, "Dibenzocyclooctyne": { "zh": "二苯并环辛炔" }, "Dual-Target RNAi Drug": { "zh": "双靶点RNAi药物" }, "ECO GMP Manufacturing Center": { "zh": "ECO GMP生产中心" }, "ECO Synthesis platform": { "zh": "ECO Synthesis平台" }, "ECO ligase": { "zh": "ECO连接酶" }, "FDA/CDER": { "zh": "FDA/CDER" }, "Factor XI": { "zh": "凝血因子XI" }, "Fall Line Endurance Fund": { "zh": "Fall Line Endurance Fund" }, "Full-Length Product": { "zh": "全长产物" }, "G5 GalNAc support": { "zh": "G5 GalNAc载体" }, "G5 ribofuranose": { "zh": "G5核糖呋喃糖" }, "GDOC": { "zh": "GDOC平台" }, "GDOC platform": { "zh": "GDOC平台" }, "GEMINI™": { "zh": "GEMINI™平台" }, "GMP-grade QC enzyme panel": { "zh": "GMP级质控酶组合" }, "GT-multi-siRNA": { "zh": "GT-multi-siRNA" }, "GalAhead": { "zh": "GalAhead™" }, "GalNAc-PA": { "zh": "GalNAc-亚磷酰胺(GalNAc-PA)" }, "GalNAc-siRNA": { "zh": "GalNAc-siRNA" }, "GalT": { "zh": "GalT" }, "GnTI": { "zh": "GnTI" }, "GreenLight Biosciences": { "zh": "GreenLight Biosciences" }, "H1 subunit": { "zh": "H1亚基" }, "H2 subunit": { "zh": "H2亚基" }, "Hongene": { "zh": "兆维" }, "Host-Cell Protein": { "zh": "宿主细胞蛋白" }, "Huntingtin": { "zh": "亨廷顿蛋白" }, "Hydroxyprolinol scaffold": { "zh": "羟脯氨醇(tHP)骨架" }, "ICH Q11 Q&A": { "zh": "ICH Q11问答" }, "ICH Q13": { "zh": "ICH Q13" }, "ICH Q2(R1)": { "zh": "ICH Q2(R1)" }, "ICH Q3D(R2)": { "zh": "ICH Q3D(R2)" }, "ICP-MS": { "zh": "ICP-MS" }, "IND-to-dosing gap": { "zh": "IND获批与首次给药时间差" }, "IVT": { "zh": "体外转录" }, "Just Climate": { "zh": "Just Climate" }, "Kd": { "zh": "Kd值" }, "Kinovate Life Sciences": { "zh": "Kinovate Life Sciences" }, "L96 ligand": { "zh": "L96配体" }, "LDL-C": { "zh": "LDL-C" }, "LGC Biosearch Technologies": { "zh": "LGC Biosearch Technologies" }, "Leloir glycosyltransferases": { "zh": "Leloir糖基转移酶" }, "Locked Nucleic Acid": { "zh": "锁核酸" }, "Lp(a)": { "zh": "Lp(a)" }, "ManII": { "zh": "ManII" }, "Maywavee": { "confidence": "high", "en_full": "Mabwell", "issue": "term 'Maywavee' 为拼写错误,正确英文名为 'Mabwell',中文规范译名为 '迈威生物'。搜索结果中多条权威医药媒体(新药情报库、医药魔方)均确认 Mabwell → 迈威生物的对应关系。", "sources": [ "https://synapse.zhihuiya.com/blog/%E8%BF%88%E5%A8%81%E7%94%9F%E7%89%A910%E4%BA%BF%E7%BE%8Eyuan%E5%8F%8C%E9%9D%B6sirna%E8%8D%AF%E7%89%A9newco%E5%85%A8%E7%90%83%E6%88%98%E7%95%A5%E8%B5%B7%E8%88%AA", "https://synapse.zhihuiya.com/blog/%E8%BF%88%E5%A8%81%E7%94%9F%E7%89%A910%E4%BA%BF%E7%BE%8Eyuan%E5%8F%8C%E9%9D%B6%E7%82%B9sirna%E6%96%B0%E8%8D%AF%E6%88%90%E5%8A%9F%E7%AD%BE%E7%BD%B2newco%E4%BA%A4%E6%98%93", "https://bydrug.pharmcube.com/news/detail/06fbf6f2e1174c99eb5f99dc8cceaef8" ], "verified_at": "2026-04-22", "zh": "迈威生物" }, "MutS Homolog 3": { "zh": "MutS同源物3" }, "N-acetylgalactosamine": { "zh": "N-乙酰半乳糖胺" }, "NAG37": { "zh": "NAG37" }, "NDA": { "zh": "新药申请" }, "NMPA": { "zh": "国家药品监督管理局" }, "Nitto Denko Avecia": { "zh": "Nitto Denko Avecia" }, "NittoPhase HL": { "zh": "NittoPhase HL" }, "Norroa": { "zh": "Norroa" }, "Notice No. 21 of 2026": { "zh": "2026年第21号通告" }, "Nuclease P1": { "zh": "核酸酶P1" }, "Nucleoside Triphosphate": { "zh": "核苷三磷酸" }, "OPR&D": { "zh": "《有机工艺研究与开发》(OPR&D)" }, "PCSK9": { "zh": "PCSK9" }, "PDE": { "zh": "允许日暴露量" }, "PMO synthesis": { "zh": "PMO合成" }, "PVA entrapment": { "zh": "PVA包埋" }, "Phosphodiester linker": { "zh": "磷酸二酯接头" }, "Polynucleotide Kinase (T4)": { "zh": "多核苷酸激酶(T4)" }, "Poresyn Solutions": { "zh": "Poresyn Solutions" }, "Prime Synthesis CPG": { "zh": "Prime Synthesis CPG" }, "PrimeMax siRNA CPG": { "zh": "PrimeMax siRNA CPG" }, "Process Analytical Technology": { "zh": "过程分析技术" }, "Process Atlas": { "zh": "工艺图谱" }, "Process Mass Intensity": { "zh": "工艺质量强度" }, "Q3M": { "zh": "Q3M" }, "Q6M": { "zh": "Q6M" }, "QC biocatalyst": { "zh": "质控生物催化剂" }, "RADS™": { "zh": "RADS™" }, "RNA interference": { "confidence": "high", "en_full": "RNA interference", "issue": "", "sources": [ "https://www.ronatherapeutics.com/cn/news/45", "https://www.zhihuiya.com/news/info_12579.html", "https://www.delveinsight.com/report-store/rna-interference-therapy-competitive-landscape" ], "verified_at": "2026-04-22", "zh": "RNA干扰" }, "RNA-Induced Silencing Complex": { "zh": "RNA诱导沉默复合体" }, "RNase A": { "zh": "核糖核酸酶A" }, "RNase H": { "zh": "核糖核酸酶H" }, "RNase Inhibitor": { "zh": "RNase Inhibitor" }, "RNase T1": { "zh": "核糖核酸酶T1" }, "RSC 2.0 modification": { "zh": "RSC 2.0修饰" }, "RiboGalSTAR™": { "zh": "RiboGalSTAR™" }, "Ribonuclease T1": { "zh": "核糖核酸酶T1" }, "Roche Custom Biotech": { "zh": "罗氏定制生物技术" }, "SBIA": { "zh": "SBIA" }, "SBS": { "zh": "SBS" }, "SMART Digest RNase T1 kit": { "zh": "SMART Digest RNase T1试剂盒" }, "SPOS": { "zh": "固相合成(SPOS)" }, "ST Pharm": { "zh": "ST Pharm" }, "STP122G": { "zh": "STP122G" }, "SUGAR-TARGET glycosyl-transferase cascade": { "zh": "SUGAR-TARGET糖基转移酶级联反应" }, "Sangon Biotech": { "zh": "生工" }, "SiaT": { "zh": "SiaT" }, "Snake Venom Phosphodiesterase": { "zh": "蛇毒磷酸二酯酶" }, "Sollbruchstellen": { "zh": "易断位点" }, "SpyCatcher/SpyTag": { "zh": "SpyCatcher/SpyTag" }, "Strain-Promoted Azide–Alkyne Cycloaddition": { "zh": "应变促进叠氮–炔烃环加成" }, "Supply-Chain Opportunity Map": { "zh": "供应链机会地图" }, "Suzhou Taike": { "zh": "苏州泰科" }, "Synthesis Modality": { "zh": "合成模式" }, "T4 RNA Ligase 1": { "zh": "T4 RNA连接酶1" }, "T4 RNA Ligase 2": { "zh": "T4 RNA连接酶2" }, "T7 RNA polymerase": { "zh": "T7 RNA聚合酶" }, "TRL": { "zh": "技术成熟度" }, "TRiM™": { "zh": "TRiM™平台" }, "Takara Bio": { "zh": "宝生物工程" }, "Technical Guidelines for Pharmaceutical Research on Chemically Synthesized Oligonucleotide Drugs (Innovative Drugs)": { "zh": "化学合成寡核苷酸药物(创新药)药学研究技术指导原则(试行)" }, "Terminal Deoxynucleotidyl Transferase": { "zh": "末端脱氧核苷酸转移酶" }, "Tianjin Orilife": { "zh": "天津奥利法" }, "Tier 1": { "zh": "第一层级" }, "Tier 2": { "zh": "第二层级" }, "Tier 3": { "zh": "第三层级" }, "Triazole linker": { "zh": "三唑接头" }, "TrisGal-6 scaffold": { "zh": "TrisGal-6骨架" }, "UDP-Gal": { "zh": "UDP-Gal" }, "UDP-GalNAc": { "zh": "UDP-GalNAc" }, "Unylinker-functionalized polystyrene support": { "zh": "Unylinker功能化聚苯乙烯载体" }, "Vazyme": { "zh": "诺唯赞" }, "Worthington Biochemical": { "zh": "Worthington Biochemical" }, "WuXi AppTec": { "zh": "药明康德" }, "Wuhu Huaren": { "zh": "芜湖华仁" }, "XBP-1": { "zh": "XBP-1" }, "Yeasen Biotech": { "zh": "翌圣生物科技" }, "acceptable daily intake": { "zh": "每日可接受摄入量" }, "activated-intermediate shelf life": { "zh": "活化中间体货架期" }, "anion-exchange polishing": { "zh": "阴离子交换精制" }, "antisolvent": { "zh": "反溶剂" }, "arm-coupling reaction": { "zh": "臂偶联反应" }, "atom-economy penalty": { "zh": "原子经济性损失" }, "avidity plateau": { "zh": "亲合力平台" }, "bead attrition": { "zh": "微珠磨损" }, "bottom-up mapping": { "zh": "自下而上图谱分析" }, "branching-point coupling": { "zh": "分支点偶联" }, "bundled enzyme-carrier product": { "zh": "酶-载体捆绑产品" }, "cardiometabolic disease": { "zh": "心脏代谢疾病" }, "cell-free synthesis": { "zh": "无细胞合成" }, "channeling": { "zh": "沟流" }, "charge-state deconvolution": { "zh": "电荷态反卷积" }, "chemoenzymatic": { "zh": "化学酶法" }, "choline chloride/glycerol": { "zh": "氯化胆碱/甘油" }, "choline chloride/urea (reline)": { "zh": "氯化胆碱/尿素(reline)" }, "class extension": { "zh": "品类延伸" }, "clinical translation": { "zh": "临床转化" }, "cluster-arm variants": { "zh": "簇臂变体" }, "co-dosing program": { "zh": "联合给药项目" }, "cocktail formulation": { "zh": "鸡尾酒制剂" }, "complement dysregulation": { "zh": "补体失调" }, "continuous process verification": { "zh": "连续工艺验证" }, "continuous-flow microgel reactor": { "zh": "连续流微凝胶反应器" }, "control threshold": { "zh": "控制阈值" }, "convergent assembly": { "zh": "汇聚式组装" }, "copper scavenging": { "zh": "铜清除" }, "copper-residue burden": { "zh": "铜残留合规负担" }, "coronary heart disease": { "zh": "冠心病" }, "covalently-linked tandem siRNA": { "zh": "共价连接串联siRNA" }, "cross-activity": { "zh": "交叉活性" }, "denaturing IP-RP-LC-MS": { "zh": "变性离子对反相液相色谱-质谱" }, "dendritic scaffold": { "zh": "树枝状骨架" }, "design paradigm": { "zh": "设计范式" }, "di-valent branched construct": { "zh": "二价分支构建体" }, "diamine scaffold": { "zh": "二胺骨架" }, "disulfide bond": { "zh": "二硫键" }, "domestic-substitution feasibility": { "zh": "国产替代可行性" }, "droplet microfluidics": { "zh": "液滴微流控技术" }, "dsRNA": { "zh": "dsRNA" }, "dual-functional RNAi therapeutic": { "zh": "双功能RNAi治疗药物" }, "enantiomeric excess": { "zh": "对映体过量值" }, "enzymatic-ligation": { "zh": "酶连接" }, "enzyme loading per gram": { "zh": "每克载体酶载量" }, "fixed-bed copper-scavenging resin": { "zh": "固定床铜清除树脂" }, "glutaraldehyde": { "zh": "戊二醛" }, "glycosyl-transferase": { "zh": "糖基转移酶" }, "hepatic parenchymal clearance": { "zh": "肝实质清除率" }, "hetero-duplex": { "zh": "异源双链体" }, "hexaethyleneglycol": { "zh": "六乙二醇" }, "hexavalent GalNAc cluster": { "zh": "六价GalNAc簇" }, "high-load polymeric support": { "zh": "高载量聚合物载体" }, "homo-duplex": { "zh": "同源双链体" }, "hypertriglyceridemia": { "zh": "高甘油三酯血症" }, "immobilized enzyme": { "zh": "固定化酶" }, "immobilized polymerase/phosphatase reactor": { "zh": "固定化聚合酶/磷酸酶反应器" }, "inline conversion monitoring": { "zh": "在线转化率监测" }, "inter-lot specific activity variation": { "zh": "批间比活力变异" }, "junction-verification assay": { "zh": "连接位点验证检测" }, "lenticular beads": { "zh": "扁豆形微珠" }, "lipid nanoparticle": { "zh": "脂质纳米颗粒" }, "liquid-phase oligonucleotide synthesis": { "zh": "液相寡核苷酸合成" }, "liquid-phase synthesis": { "zh": "液相合成" }, "mRNAi GOLD™": { "zh": "mRNAi GOLD™" }, "maleimide-activated agarose": { "zh": "马来酰亚胺活化琼脂糖" }, "manufacturing stack": { "zh": "制造体系" }, "material diversion strategy": { "zh": "物料转移策略" }, "membrane bioreactor": { "zh": "膜生物反应器" }, "methacrylate copolymer beads": { "zh": "甲基丙烯酸酯共聚物微珠" }, "mixed hyperlipidemia": { "zh": "混合型高脂血症" }, "monoantennary GalNAc": { "zh": "单天线GalNAc" }, "monomer diversity index": { "zh": "单体多样性指标" }, "muRNA": { "zh": "muRNA" }, "multivalent GalNAc cluster": { "zh": "多价GalNAc簇" }, "multivalent GalNAc scaffold": { "zh": "多价GalNAc骨架" }, "murine TdT": { "zh": "鼠源TdT" }, "mxRNA": { "zh": "mxRNA" }, "neurodegeneration": { "zh": "神经退行性疾病" }, "nonclinical guidance": { "zh": "非临床指南" }, "nuclease mapping": { "zh": "核酸酶图谱分析" }, "packed-bed reactor": { "zh": "填充床反应器" }, "partially conjugated strand": { "zh": "部分偶联链" }, "particle-integrity monitoring": { "zh": "颗粒完整性监测" }, "pentavalent GalNAc": { "zh": "五价GalNAc" }, "phosphoramidite monomer": { "confidence": "high", "en_full": "phosphoramidite monomer", "issue": "", "sources": [ "https://broadpharm.com/blog/Modified-Phosphoramidites-in-RNAi-Research", "https://www.ractigen.com/sirna-aco-is-a-convenient-phosphoramidite-based-conjugate-that-enables-rnai-in-the-cns-via-local-administration-with-superior-efficacy-in-the-treatment-of-als-rodent-models-poster/", "https://pmc.ncbi.nlm.nih.gov/articles/PMC11472056/" ], "verified_at": "2026-04-22", "zh": "亚磷酰胺单体" }, "pipeline inflation": { "zh": "管线虚胖" }, "platform-multiplication event": { "zh": "平台倍增事件" }, "polymer microgels": { "zh": "聚合物微凝胶" }, "pre-validated package": { "zh": "预验证文件包" }, "pressure-drop effects": { "zh": "压降效应" }, "process debt": { "zh": "工艺债务" }, "process node": { "zh": "工艺节点" }, "process signature": { "zh": "工艺特征" }, "product-specific guidance": { "zh": "产品专项指南" }, "protecting-group strategy": { "zh": "保护基策略" }, "protective allele": { "zh": "保护性等位基因" }, "pyranose": { "zh": "吡喃糖" }, "qualification barrier": { "zh": "资质壁垒" }, "rSAP": { "zh": "rSAP" }, "ratio QC": { "zh": "比例质控" }, "receptor-mediated uptake": { "zh": "受体内吞" }, "regulatory vector": { "zh": "监管向量" }, "release-profile QC": { "zh": "释放谱质控" }, "residual enzyme surveillance": { "zh": "残留酶监控" }, "ribofuranose scaffold": { "zh": "核糖呋喃糖骨架" }, "serially assembled trivalent construct": { "zh": "序贯组装三价构建体" }, "siRELIS facility": { "zh": "siRELIS工厂" }, "silica bead fines": { "zh": "硅胶微珠细粉" }, "solid-phase phosphoramidite synthesis": { "zh": "固相亚磷酰胺合成" }, "solid-phase synthesis": { "zh": "固相合成" }, "soluble anchor": { "zh": "可溶性锚定基团" }, "spacer accessibility": { "zh": "间隔臂可及性" }, "splint removal": { "zh": "DNA夹板去除" }, "streptavidin-coated silica beads": { "zh": "链霉亲和素包被硅胶微珠" }, "structure-activity study": { "zh": "构效关系研究" }, "sub-saturation binding regime": { "zh": "未饱和结合区间" }, "supplier concentration": { "zh": "供应商集中度" }, "swelling index": { "zh": "溶胀指数" }, "tetraantennary": { "zh": "四天线" }, "tetraloop": { "zh": "四环体" }, "top-down intact-mass sequencing": { "zh": "自上而下完整质量测序" }, "toxicokinetic subfactor justification": { "zh": "毒代动力学亚因子论证" }, "triantennary GalNAc": { "zh": "三天线GalNAc" }, "truncated cluster impurity": { "zh": "截短型簇杂质" } }