\u7ee7\u7eed\u89e3\u51b3\u7528\u6237\u53cd\u9988\u7684 PDF \u95ee\u9898\u3002
scripts/build_report.py\uff08\u65b0\u589e\uff09\uff1a
- \u5355\u4e00\u5165\u53e3\u540c\u65f6\u51fa PDF + DOCX
- \u6587\u4ef6\u540d\u81ea\u52a8\u4ece manifest.report_title \u751f\u6210\uff08\u89e3\u51b3 "final.pdf" \u6CDB\u540d\u95EE\u9898\uff09
- pandoc --from=markdown-tex_math_dollars \u4fee\u590d DOCX \u751f\u6210\u65f6\u7684 $ \u8bef\u89e3
- \u81ea\u52a8\u5bfb\u627e phase2/sources.jsonl \u4f5c\u4e3a\u53c2\u8003\u6587\u732e\u5f15\u6587\u6e90
scripts/lib/search_client.py\uff08\u65b0\u589e\uff09\uff1a
- Exa \u4e3b\u529b + Tavily fallback \u7684\u7edf\u4e00\u63a5\u53e3
- \u5173\u952e\u4fee\u590d\uff1atrust_env=False \u7ed5\u5f00\u7cfb\u7edf socks5 \u4ee3\u7406
\uff08Clash on macOS \u5c0a httpx TLS \u63e1\u624b\u5728 CONNECT \u540e EOF\uff09
scripts/build_glossary.py\uff08\u65b0\u589e\uff09\uff1a
- \u7528\u7684\u4e92\u65b9\u5f0f\u89e3\u51b3\u4e86\u7528\u6237\u53cd\u9988 #6\uff1a\u672f\u8bed\u7ffb\u8bd1\u4e0d\u4e13\u4e1a / \u4e8b\u5b9e\u9519\u8bef
- ThreadPoolExecutor \u5e76\u53d1\uff08\u9ed8\u8ba4 6 worker\uff09\uff0c\u6bcf\u4e2a\u672f\u8bed\u72ec\u7acb\uff1a
Search \u2192 Top-3 snippet \u2192 Haiku \u5224\u5b9a \u2192 \u8fd4\u56de {zh, en_full, confidence, issue}
- \u5b9e\u6d4b\u6210\u529f\u8bc6\u522b "Maywavee" \u4e3a "Mabwell" \u7684\u62fc\u5199\u9519\u8bef\u5e76\u6807\u51fa issue
- \u65ad\u70b9\u7eed\u4f20\uff08\u5df2\u6807 verified_at \u7684\u9ed8\u8ba4\u8df3\u8fc7\uff09
- Haiku \u6210\u672c\u6781\u4f4e\uff083 \u4e2a\u672f\u8bed\u8c03\u7528 \u2248 0.01 \u7f8e\u5206\uff09
- \u652f\u6301 --extra terms.txt \u8865\u5145\u7ffb\u8bd1\u9636\u6bb5\u672a\u6536\u5165\u7684\u672f\u8bed
scripts/prompts/glossary_system.txt\uff08\u65b0\u589e\uff09\uff1a
- Haiku \u6838\u67e5\u672f\u8bed\u7684 prompt\uff0c\u660e\u786e\u5224\u5b9a\u7ef4\u5ea6\u548c JSON \u8f93\u51fa\u683c\u5f0f
Co-authored-by: User <human>
960 lines
20 KiB
JSON
960 lines
20 KiB
JSON
{
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||
"2'-F-CTP": {
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"zh": "2'-F-CTP"
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},
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"2'-F-UTP": {
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"zh": "2'-F-UTP"
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},
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"2'-OMe-ATP": {
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"zh": "2'-OMe-ATP"
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},
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"2'-OMe-UTP": {
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"zh": "2'-OMe-UTP"
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},
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"2'-acetal levulinic ester (ALE) phosphoramidite": {
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"zh": "2'-缩醛乙酰丙酸酯(ALE)亚磷酰胺"
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},
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"32P-end-labeling": {
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"zh": "32P末端标记"
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},
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"500 Å pore": {
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"zh": "500 Å孔径"
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},
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"AGT": {
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"zh": "AGT"
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},
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"AJIPHASE®": {
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"zh": "AJIPHASE®"
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},
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"ANGPTL3": {
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"zh": "ANGPTL3"
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},
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"AOF formulation": {
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"zh": "无动物及人源成分(AOF)配方"
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},
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"API sameness": {
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"zh": "API同一性"
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},
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"APOC3": {
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"zh": "APOC3"
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},
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"ASCVD": {
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"zh": "动脉粥样硬化性心血管疾病"
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},
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"ASGPR": {
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"zh": "去唾液酸糖蛋白受体"
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},
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"ASMF": {
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"zh": "ASMF备案"
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},
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"Adaptive Laboratory Evolution": {
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"zh": "适应性实验室进化"
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},
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"Ajinomoto Bio-Pharma Services": {
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"zh": "味之素生物制药服务"
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},
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"Ajinomoto OmniChem": {
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"zh": "Ajinomoto OmniChem"
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},
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"Amide linker": {
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"zh": "酰胺接头"
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},
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"Angiotensinogen": {
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"zh": "血管紧张素原"
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},
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"Antibody-Drug Conjugate": {
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"zh": "抗体偶联药物"
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},
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"BD value": {
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"zh": "BD交易价值"
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},
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"BIOSECURE Act": {
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"zh": "《生物安全法案》"
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},
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"BTT activation": {
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"zh": "BTT活化"
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},
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"Bachem": {
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"zh": "Bachem"
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},
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"BeBetter Med": {
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"zh": "必贝特"
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},
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"Beyotime": {
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"zh": "碧云天"
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},
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"Biologics License Application": {
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"zh": "生物制品上市许可申请"
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},
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"Biomaide": {
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"zh": "博迈德"
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},
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"BirA/AviTag": {
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"zh": "BirA/AviTag"
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},
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"Bis-RNAi": {
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"zh": "Bis-RNAi"
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},
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"C5": {
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"zh": "C5"
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},
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"CDE": {
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"zh": "药品审评中心"
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},
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"CDMO": {
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"zh": "合同开发与生产组织"
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},
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"CID fragmentation": {
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"zh": "碰撞诱导解离(CID)碎裂"
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},
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"CLEA-LentiKats lipase formulation": {
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"zh": "CLEA-LentiKats脂肪酶制剂"
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},
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"CMC development timeline": {
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"zh": "CMC开发周期"
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},
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"CPG support": {
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"zh": "CPG载体"
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},
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"CTA": {
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"zh": "临床试验申请"
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},
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"Calantha™": {
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"zh": "Calantha™"
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},
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"Calf Intestinal Alkaline Phosphatase": {
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"zh": "小牛肠碱性磷酸酶"
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},
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"Candida antarctica lipase B": {
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"zh": "南极假丝酵母脂肪酶B"
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},
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"Category I": {
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"zh": "第I类"
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},
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"Category II": {
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"zh": "第II类"
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},
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"Category III": {
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"zh": "第III类"
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},
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"Category IV": {
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"zh": "第IV类"
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},
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"ChemGenes": {
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"zh": "ChemGenes"
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},
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"Chinese IND": {
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"zh": "中国IND"
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},
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"Class 3": {
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"zh": "第3类"
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},
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"Complement Factor B": {
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"zh": "补体因子B"
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},
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"Complete Response Letter": {
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"zh": "完全答复函"
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},
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"Controlled pore glass": {
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"zh": "受控孔径玻璃"
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},
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"Cross-Linked Enzyme Aggregates": {
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"zh": "交联酶聚集体"
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},
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"CuAAC": {
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"zh": "铜催化叠氮-炔烃环加成"
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},
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"D-galactosamine": {
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"zh": "D-半乳糖胺"
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},
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"DBCO": {
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"zh": "二苯并环辛炔(DBCO)"
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},
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"DMF": {
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"zh": "DMF备案"
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},
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"DMT-on HPLC purification handle": {
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"zh": "DMT-on HPLC纯化把手"
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},
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"DNase I": {
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"zh": "DNase I"
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},
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"Deep Eutectic Solvent": {
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"zh": "深共熔溶剂"
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},
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"Dibenzocyclooctyne": {
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"zh": "二苯并环辛炔"
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},
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"Dual-Target RNAi Drug": {
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"zh": "双靶点RNAi药物"
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},
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"ECO GMP Manufacturing Center": {
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"zh": "ECO GMP生产中心"
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},
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"ECO Synthesis platform": {
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"zh": "ECO Synthesis平台"
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},
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"ECO ligase": {
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"zh": "ECO连接酶"
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},
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"FDA/CDER": {
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"zh": "FDA/CDER"
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},
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"Factor XI": {
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"zh": "凝血因子XI"
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},
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"Fall Line Endurance Fund": {
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"zh": "Fall Line Endurance Fund"
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},
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"Full-Length Product": {
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"zh": "全长产物"
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},
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"G5 GalNAc support": {
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"zh": "G5 GalNAc载体"
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},
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"G5 ribofuranose": {
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"zh": "G5核糖呋喃糖"
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},
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"GDOC": {
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"zh": "GDOC平台"
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},
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"GDOC platform": {
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"zh": "GDOC平台"
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},
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"GEMINI™": {
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"zh": "GEMINI™平台"
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},
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"GMP-grade QC enzyme panel": {
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"zh": "GMP级质控酶组合"
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},
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"GT-multi-siRNA": {
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"zh": "GT-multi-siRNA"
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},
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"GalAhead": {
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"zh": "GalAhead™"
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},
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"GalNAc-PA": {
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"zh": "GalNAc-亚磷酰胺(GalNAc-PA)"
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},
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"GalNAc-siRNA": {
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"zh": "GalNAc-siRNA"
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},
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"GalT": {
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"zh": "GalT"
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},
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"GnTI": {
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"zh": "GnTI"
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},
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"GreenLight Biosciences": {
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"zh": "GreenLight Biosciences"
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},
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"H1 subunit": {
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"zh": "H1亚基"
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},
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"H2 subunit": {
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"zh": "H2亚基"
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},
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"Hongene": {
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"zh": "兆维"
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},
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"Host-Cell Protein": {
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"zh": "宿主细胞蛋白"
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},
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"Huntingtin": {
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"zh": "亨廷顿蛋白"
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},
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"Hydroxyprolinol scaffold": {
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"zh": "羟脯氨醇(tHP)骨架"
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},
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"ICH Q11 Q&A": {
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"zh": "ICH Q11问答"
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},
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"ICH Q13": {
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"zh": "ICH Q13"
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},
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"ICH Q2(R1)": {
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"zh": "ICH Q2(R1)"
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},
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"ICH Q3D(R2)": {
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"zh": "ICH Q3D(R2)"
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},
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"ICP-MS": {
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"zh": "ICP-MS"
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},
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"IND-to-dosing gap": {
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"zh": "IND获批与首次给药时间差"
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},
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"IVT": {
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"zh": "体外转录"
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},
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"Just Climate": {
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"zh": "Just Climate"
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},
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"Kd": {
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"zh": "Kd值"
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},
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"Kinovate Life Sciences": {
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"zh": "Kinovate Life Sciences"
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},
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"L96 ligand": {
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"zh": "L96配体"
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},
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"LDL-C": {
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"zh": "LDL-C"
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},
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"LGC Biosearch Technologies": {
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"zh": "LGC Biosearch Technologies"
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},
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"Leloir glycosyltransferases": {
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"zh": "Leloir糖基转移酶"
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},
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"Locked Nucleic Acid": {
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"zh": "锁核酸"
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},
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"Lp(a)": {
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"zh": "Lp(a)"
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},
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"ManII": {
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"zh": "ManII"
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},
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"Maywavee": {
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"confidence": "high",
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"en_full": "Mabwell",
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"issue": "term 'Maywavee' 为拼写错误,正确英文名为 'Mabwell',中文规范译名为 '迈威生物'。搜索结果中多条权威医药媒体(新药情报库、医药魔方)均确认 Mabwell → 迈威生物的对应关系。",
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"sources": [
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"https://synapse.zhihuiya.com/blog/%E8%BF%88%E5%A8%81%E7%94%9F%E7%89%A910%E4%BA%BF%E7%BE%8Eyuan%E5%8F%8C%E9%9D%B6sirna%E8%8D%AF%E7%89%A9newco%E5%85%A8%E7%90%83%E6%88%98%E7%95%A5%E8%B5%B7%E8%88%AA",
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"https://synapse.zhihuiya.com/blog/%E8%BF%88%E5%A8%81%E7%94%9F%E7%89%A910%E4%BA%BF%E7%BE%8Eyuan%E5%8F%8C%E9%9D%B6%E7%82%B9sirna%E6%96%B0%E8%8D%AF%E6%88%90%E5%8A%9F%E7%AD%BE%E7%BD%B2newco%E4%BA%A4%E6%98%93",
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"https://bydrug.pharmcube.com/news/detail/06fbf6f2e1174c99eb5f99dc8cceaef8"
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],
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"verified_at": "2026-04-22",
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"zh": "迈威生物"
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},
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"MutS Homolog 3": {
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"zh": "MutS同源物3"
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},
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"N-acetylgalactosamine": {
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"zh": "N-乙酰半乳糖胺"
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},
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"NAG37": {
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"zh": "NAG37"
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},
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"NDA": {
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"zh": "新药申请"
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},
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"NMPA": {
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"zh": "国家药品监督管理局"
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},
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"Nitto Denko Avecia": {
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"zh": "Nitto Denko Avecia"
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},
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"NittoPhase HL": {
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"zh": "NittoPhase HL"
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},
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"Norroa": {
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"zh": "Norroa"
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},
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"Notice No. 21 of 2026": {
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"zh": "2026年第21号通告"
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},
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"Nuclease P1": {
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"zh": "核酸酶P1"
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},
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"Nucleoside Triphosphate": {
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"zh": "核苷三磷酸"
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},
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"OPR&D": {
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"zh": "《有机工艺研究与开发》(OPR&D)"
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},
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"PCSK9": {
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"zh": "PCSK9"
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},
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"PDE": {
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"zh": "允许日暴露量"
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},
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"PMO synthesis": {
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"zh": "PMO合成"
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},
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"PVA entrapment": {
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"zh": "PVA包埋"
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},
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"Phosphodiester linker": {
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"zh": "磷酸二酯接头"
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},
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"Polynucleotide Kinase (T4)": {
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"zh": "多核苷酸激酶(T4)"
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},
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"Poresyn Solutions": {
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"zh": "Poresyn Solutions"
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},
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"Prime Synthesis CPG": {
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"zh": "Prime Synthesis CPG"
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},
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"PrimeMax siRNA CPG": {
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"zh": "PrimeMax siRNA CPG"
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},
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"Process Analytical Technology": {
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"zh": "过程分析技术"
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},
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"Process Atlas": {
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"zh": "工艺图谱"
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},
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"Process Mass Intensity": {
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"zh": "工艺质量强度"
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},
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"Q3M": {
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"zh": "Q3M"
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},
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"Q6M": {
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"zh": "Q6M"
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},
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"QC biocatalyst": {
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"zh": "质控生物催化剂"
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},
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"RADS™": {
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"zh": "RADS™"
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},
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"RNA interference": {
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"confidence": "high",
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"en_full": "RNA interference",
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"issue": "",
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"sources": [
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"https://www.ronatherapeutics.com/cn/news/45",
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"https://www.zhihuiya.com/news/info_12579.html",
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"https://www.delveinsight.com/report-store/rna-interference-therapy-competitive-landscape"
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],
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"verified_at": "2026-04-22",
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"zh": "RNA干扰"
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},
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"RNA-Induced Silencing Complex": {
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"zh": "RNA诱导沉默复合体"
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},
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"RNase A": {
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"zh": "核糖核酸酶A"
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},
|
||
"RNase H": {
|
||
"zh": "核糖核酸酶H"
|
||
},
|
||
"RNase Inhibitor": {
|
||
"zh": "RNase Inhibitor"
|
||
},
|
||
"RNase T1": {
|
||
"zh": "核糖核酸酶T1"
|
||
},
|
||
"RSC 2.0 modification": {
|
||
"zh": "RSC 2.0修饰"
|
||
},
|
||
"RiboGalSTAR™": {
|
||
"zh": "RiboGalSTAR™"
|
||
},
|
||
"Ribonuclease T1": {
|
||
"zh": "核糖核酸酶T1"
|
||
},
|
||
"Roche Custom Biotech": {
|
||
"zh": "罗氏定制生物技术"
|
||
},
|
||
"SBIA": {
|
||
"zh": "SBIA"
|
||
},
|
||
"SBS": {
|
||
"zh": "SBS"
|
||
},
|
||
"SMART Digest RNase T1 kit": {
|
||
"zh": "SMART Digest RNase T1试剂盒"
|
||
},
|
||
"SPOS": {
|
||
"zh": "固相合成(SPOS)"
|
||
},
|
||
"ST Pharm": {
|
||
"zh": "ST Pharm"
|
||
},
|
||
"STP122G": {
|
||
"zh": "STP122G"
|
||
},
|
||
"SUGAR-TARGET glycosyl-transferase cascade": {
|
||
"zh": "SUGAR-TARGET糖基转移酶级联反应"
|
||
},
|
||
"Sangon Biotech": {
|
||
"zh": "生工"
|
||
},
|
||
"SiaT": {
|
||
"zh": "SiaT"
|
||
},
|
||
"Snake Venom Phosphodiesterase": {
|
||
"zh": "蛇毒磷酸二酯酶"
|
||
},
|
||
"Sollbruchstellen": {
|
||
"zh": "易断位点"
|
||
},
|
||
"SpyCatcher/SpyTag": {
|
||
"zh": "SpyCatcher/SpyTag"
|
||
},
|
||
"Strain-Promoted Azide–Alkyne Cycloaddition": {
|
||
"zh": "应变促进叠氮–炔烃环加成"
|
||
},
|
||
"Supply-Chain Opportunity Map": {
|
||
"zh": "供应链机会地图"
|
||
},
|
||
"Suzhou Taike": {
|
||
"zh": "苏州泰科"
|
||
},
|
||
"Synthesis Modality": {
|
||
"zh": "合成模式"
|
||
},
|
||
"T4 RNA Ligase 1": {
|
||
"zh": "T4 RNA连接酶1"
|
||
},
|
||
"T4 RNA Ligase 2": {
|
||
"zh": "T4 RNA连接酶2"
|
||
},
|
||
"T7 RNA polymerase": {
|
||
"zh": "T7 RNA聚合酶"
|
||
},
|
||
"TRL": {
|
||
"zh": "技术成熟度"
|
||
},
|
||
"TRiM™": {
|
||
"zh": "TRiM™平台"
|
||
},
|
||
"Takara Bio": {
|
||
"zh": "宝生物工程"
|
||
},
|
||
"Technical Guidelines for Pharmaceutical Research on Chemically Synthesized Oligonucleotide Drugs (Innovative Drugs)": {
|
||
"zh": "化学合成寡核苷酸药物(创新药)药学研究技术指导原则(试行)"
|
||
},
|
||
"Terminal Deoxynucleotidyl Transferase": {
|
||
"zh": "末端脱氧核苷酸转移酶"
|
||
},
|
||
"Tianjin Orilife": {
|
||
"zh": "天津奥利法"
|
||
},
|
||
"Tier 1": {
|
||
"zh": "第一层级"
|
||
},
|
||
"Tier 2": {
|
||
"zh": "第二层级"
|
||
},
|
||
"Tier 3": {
|
||
"zh": "第三层级"
|
||
},
|
||
"Triazole linker": {
|
||
"zh": "三唑接头"
|
||
},
|
||
"TrisGal-6 scaffold": {
|
||
"zh": "TrisGal-6骨架"
|
||
},
|
||
"UDP-Gal": {
|
||
"zh": "UDP-Gal"
|
||
},
|
||
"UDP-GalNAc": {
|
||
"zh": "UDP-GalNAc"
|
||
},
|
||
"Unylinker-functionalized polystyrene support": {
|
||
"zh": "Unylinker功能化聚苯乙烯载体"
|
||
},
|
||
"Vazyme": {
|
||
"zh": "诺唯赞"
|
||
},
|
||
"Worthington Biochemical": {
|
||
"zh": "Worthington Biochemical"
|
||
},
|
||
"WuXi AppTec": {
|
||
"zh": "药明康德"
|
||
},
|
||
"Wuhu Huaren": {
|
||
"zh": "芜湖华仁"
|
||
},
|
||
"XBP-1": {
|
||
"zh": "XBP-1"
|
||
},
|
||
"Yeasen Biotech": {
|
||
"zh": "翌圣生物科技"
|
||
},
|
||
"acceptable daily intake": {
|
||
"zh": "每日可接受摄入量"
|
||
},
|
||
"activated-intermediate shelf life": {
|
||
"zh": "活化中间体货架期"
|
||
},
|
||
"anion-exchange polishing": {
|
||
"zh": "阴离子交换精制"
|
||
},
|
||
"antisolvent": {
|
||
"zh": "反溶剂"
|
||
},
|
||
"arm-coupling reaction": {
|
||
"zh": "臂偶联反应"
|
||
},
|
||
"atom-economy penalty": {
|
||
"zh": "原子经济性损失"
|
||
},
|
||
"avidity plateau": {
|
||
"zh": "亲合力平台"
|
||
},
|
||
"bead attrition": {
|
||
"zh": "微珠磨损"
|
||
},
|
||
"bottom-up mapping": {
|
||
"zh": "自下而上图谱分析"
|
||
},
|
||
"branching-point coupling": {
|
||
"zh": "分支点偶联"
|
||
},
|
||
"bundled enzyme-carrier product": {
|
||
"zh": "酶-载体捆绑产品"
|
||
},
|
||
"cardiometabolic disease": {
|
||
"zh": "心脏代谢疾病"
|
||
},
|
||
"cell-free synthesis": {
|
||
"zh": "无细胞合成"
|
||
},
|
||
"channeling": {
|
||
"zh": "沟流"
|
||
},
|
||
"charge-state deconvolution": {
|
||
"zh": "电荷态反卷积"
|
||
},
|
||
"chemoenzymatic": {
|
||
"zh": "化学酶法"
|
||
},
|
||
"choline chloride/glycerol": {
|
||
"zh": "氯化胆碱/甘油"
|
||
},
|
||
"choline chloride/urea (reline)": {
|
||
"zh": "氯化胆碱/尿素(reline)"
|
||
},
|
||
"class extension": {
|
||
"zh": "品类延伸"
|
||
},
|
||
"clinical translation": {
|
||
"zh": "临床转化"
|
||
},
|
||
"cluster-arm variants": {
|
||
"zh": "簇臂变体"
|
||
},
|
||
"co-dosing program": {
|
||
"zh": "联合给药项目"
|
||
},
|
||
"cocktail formulation": {
|
||
"zh": "鸡尾酒制剂"
|
||
},
|
||
"complement dysregulation": {
|
||
"zh": "补体失调"
|
||
},
|
||
"continuous process verification": {
|
||
"zh": "连续工艺验证"
|
||
},
|
||
"continuous-flow microgel reactor": {
|
||
"zh": "连续流微凝胶反应器"
|
||
},
|
||
"control threshold": {
|
||
"zh": "控制阈值"
|
||
},
|
||
"convergent assembly": {
|
||
"zh": "汇聚式组装"
|
||
},
|
||
"copper scavenging": {
|
||
"zh": "铜清除"
|
||
},
|
||
"copper-residue burden": {
|
||
"zh": "铜残留合规负担"
|
||
},
|
||
"coronary heart disease": {
|
||
"zh": "冠心病"
|
||
},
|
||
"covalently-linked tandem siRNA": {
|
||
"zh": "共价连接串联siRNA"
|
||
},
|
||
"cross-activity": {
|
||
"zh": "交叉活性"
|
||
},
|
||
"denaturing IP-RP-LC-MS": {
|
||
"zh": "变性离子对反相液相色谱-质谱"
|
||
},
|
||
"dendritic scaffold": {
|
||
"zh": "树枝状骨架"
|
||
},
|
||
"design paradigm": {
|
||
"zh": "设计范式"
|
||
},
|
||
"di-valent branched construct": {
|
||
"zh": "二价分支构建体"
|
||
},
|
||
"diamine scaffold": {
|
||
"zh": "二胺骨架"
|
||
},
|
||
"disulfide bond": {
|
||
"zh": "二硫键"
|
||
},
|
||
"domestic-substitution feasibility": {
|
||
"zh": "国产替代可行性"
|
||
},
|
||
"droplet microfluidics": {
|
||
"zh": "液滴微流控技术"
|
||
},
|
||
"dsRNA": {
|
||
"zh": "dsRNA"
|
||
},
|
||
"dual-functional RNAi therapeutic": {
|
||
"zh": "双功能RNAi治疗药物"
|
||
},
|
||
"enantiomeric excess": {
|
||
"zh": "对映体过量值"
|
||
},
|
||
"enzymatic-ligation": {
|
||
"zh": "酶连接"
|
||
},
|
||
"enzyme loading per gram": {
|
||
"zh": "每克载体酶载量"
|
||
},
|
||
"fixed-bed copper-scavenging resin": {
|
||
"zh": "固定床铜清除树脂"
|
||
},
|
||
"glutaraldehyde": {
|
||
"zh": "戊二醛"
|
||
},
|
||
"glycosyl-transferase": {
|
||
"zh": "糖基转移酶"
|
||
},
|
||
"hepatic parenchymal clearance": {
|
||
"zh": "肝实质清除率"
|
||
},
|
||
"hetero-duplex": {
|
||
"zh": "异源双链体"
|
||
},
|
||
"hexaethyleneglycol": {
|
||
"zh": "六乙二醇"
|
||
},
|
||
"hexavalent GalNAc cluster": {
|
||
"zh": "六价GalNAc簇"
|
||
},
|
||
"high-load polymeric support": {
|
||
"zh": "高载量聚合物载体"
|
||
},
|
||
"homo-duplex": {
|
||
"zh": "同源双链体"
|
||
},
|
||
"hypertriglyceridemia": {
|
||
"zh": "高甘油三酯血症"
|
||
},
|
||
"immobilized enzyme": {
|
||
"zh": "固定化酶"
|
||
},
|
||
"immobilized polymerase/phosphatase reactor": {
|
||
"zh": "固定化聚合酶/磷酸酶反应器"
|
||
},
|
||
"inline conversion monitoring": {
|
||
"zh": "在线转化率监测"
|
||
},
|
||
"inter-lot specific activity variation": {
|
||
"zh": "批间比活力变异"
|
||
},
|
||
"junction-verification assay": {
|
||
"zh": "连接位点验证检测"
|
||
},
|
||
"lenticular beads": {
|
||
"zh": "扁豆形微珠"
|
||
},
|
||
"lipid nanoparticle": {
|
||
"zh": "脂质纳米颗粒"
|
||
},
|
||
"liquid-phase oligonucleotide synthesis": {
|
||
"zh": "液相寡核苷酸合成"
|
||
},
|
||
"liquid-phase synthesis": {
|
||
"zh": "液相合成"
|
||
},
|
||
"mRNAi GOLD™": {
|
||
"zh": "mRNAi GOLD™"
|
||
},
|
||
"maleimide-activated agarose": {
|
||
"zh": "马来酰亚胺活化琼脂糖"
|
||
},
|
||
"manufacturing stack": {
|
||
"zh": "制造体系"
|
||
},
|
||
"material diversion strategy": {
|
||
"zh": "物料转移策略"
|
||
},
|
||
"membrane bioreactor": {
|
||
"zh": "膜生物反应器"
|
||
},
|
||
"methacrylate copolymer beads": {
|
||
"zh": "甲基丙烯酸酯共聚物微珠"
|
||
},
|
||
"mixed hyperlipidemia": {
|
||
"zh": "混合型高脂血症"
|
||
},
|
||
"monoantennary GalNAc": {
|
||
"zh": "单天线GalNAc"
|
||
},
|
||
"monomer diversity index": {
|
||
"zh": "单体多样性指标"
|
||
},
|
||
"muRNA": {
|
||
"zh": "muRNA"
|
||
},
|
||
"multivalent GalNAc cluster": {
|
||
"zh": "多价GalNAc簇"
|
||
},
|
||
"multivalent GalNAc scaffold": {
|
||
"zh": "多价GalNAc骨架"
|
||
},
|
||
"murine TdT": {
|
||
"zh": "鼠源TdT"
|
||
},
|
||
"mxRNA": {
|
||
"zh": "mxRNA"
|
||
},
|
||
"neurodegeneration": {
|
||
"zh": "神经退行性疾病"
|
||
},
|
||
"nonclinical guidance": {
|
||
"zh": "非临床指南"
|
||
},
|
||
"nuclease mapping": {
|
||
"zh": "核酸酶图谱分析"
|
||
},
|
||
"packed-bed reactor": {
|
||
"zh": "填充床反应器"
|
||
},
|
||
"partially conjugated strand": {
|
||
"zh": "部分偶联链"
|
||
},
|
||
"particle-integrity monitoring": {
|
||
"zh": "颗粒完整性监测"
|
||
},
|
||
"pentavalent GalNAc": {
|
||
"zh": "五价GalNAc"
|
||
},
|
||
"phosphoramidite monomer": {
|
||
"confidence": "high",
|
||
"en_full": "phosphoramidite monomer",
|
||
"issue": "",
|
||
"sources": [
|
||
"https://broadpharm.com/blog/Modified-Phosphoramidites-in-RNAi-Research",
|
||
"https://www.ractigen.com/sirna-aco-is-a-convenient-phosphoramidite-based-conjugate-that-enables-rnai-in-the-cns-via-local-administration-with-superior-efficacy-in-the-treatment-of-als-rodent-models-poster/",
|
||
"https://pmc.ncbi.nlm.nih.gov/articles/PMC11472056/"
|
||
],
|
||
"verified_at": "2026-04-22",
|
||
"zh": "亚磷酰胺单体"
|
||
},
|
||
"pipeline inflation": {
|
||
"zh": "管线虚胖"
|
||
},
|
||
"platform-multiplication event": {
|
||
"zh": "平台倍增事件"
|
||
},
|
||
"polymer microgels": {
|
||
"zh": "聚合物微凝胶"
|
||
},
|
||
"pre-validated package": {
|
||
"zh": "预验证文件包"
|
||
},
|
||
"pressure-drop effects": {
|
||
"zh": "压降效应"
|
||
},
|
||
"process debt": {
|
||
"zh": "工艺债务"
|
||
},
|
||
"process node": {
|
||
"zh": "工艺节点"
|
||
},
|
||
"process signature": {
|
||
"zh": "工艺特征"
|
||
},
|
||
"product-specific guidance": {
|
||
"zh": "产品专项指南"
|
||
},
|
||
"protecting-group strategy": {
|
||
"zh": "保护基策略"
|
||
},
|
||
"protective allele": {
|
||
"zh": "保护性等位基因"
|
||
},
|
||
"pyranose": {
|
||
"zh": "吡喃糖"
|
||
},
|
||
"qualification barrier": {
|
||
"zh": "资质壁垒"
|
||
},
|
||
"rSAP": {
|
||
"zh": "rSAP"
|
||
},
|
||
"ratio QC": {
|
||
"zh": "比例质控"
|
||
},
|
||
"receptor-mediated uptake": {
|
||
"zh": "受体内吞"
|
||
},
|
||
"regulatory vector": {
|
||
"zh": "监管向量"
|
||
},
|
||
"release-profile QC": {
|
||
"zh": "释放谱质控"
|
||
},
|
||
"residual enzyme surveillance": {
|
||
"zh": "残留酶监控"
|
||
},
|
||
"ribofuranose scaffold": {
|
||
"zh": "核糖呋喃糖骨架"
|
||
},
|
||
"serially assembled trivalent construct": {
|
||
"zh": "序贯组装三价构建体"
|
||
},
|
||
"siRELIS facility": {
|
||
"zh": "siRELIS工厂"
|
||
},
|
||
"silica bead fines": {
|
||
"zh": "硅胶微珠细粉"
|
||
},
|
||
"solid-phase phosphoramidite synthesis": {
|
||
"zh": "固相亚磷酰胺合成"
|
||
},
|
||
"solid-phase synthesis": {
|
||
"zh": "固相合成"
|
||
},
|
||
"soluble anchor": {
|
||
"zh": "可溶性锚定基团"
|
||
},
|
||
"spacer accessibility": {
|
||
"zh": "间隔臂可及性"
|
||
},
|
||
"splint removal": {
|
||
"zh": "DNA夹板去除"
|
||
},
|
||
"streptavidin-coated silica beads": {
|
||
"zh": "链霉亲和素包被硅胶微珠"
|
||
},
|
||
"structure-activity study": {
|
||
"zh": "构效关系研究"
|
||
},
|
||
"sub-saturation binding regime": {
|
||
"zh": "未饱和结合区间"
|
||
},
|
||
"supplier concentration": {
|
||
"zh": "供应商集中度"
|
||
},
|
||
"swelling index": {
|
||
"zh": "溶胀指数"
|
||
},
|
||
"tetraantennary": {
|
||
"zh": "四天线"
|
||
},
|
||
"tetraloop": {
|
||
"zh": "四环体"
|
||
},
|
||
"top-down intact-mass sequencing": {
|
||
"zh": "自上而下完整质量测序"
|
||
},
|
||
"toxicokinetic subfactor justification": {
|
||
"zh": "毒代动力学亚因子论证"
|
||
},
|
||
"triantennary GalNAc": {
|
||
"zh": "三天线GalNAc"
|
||
},
|
||
"truncated cluster impurity": {
|
||
"zh": "截短型簇杂质"
|
||
}
|
||
}
|